Material bank

Articles in newspapers and journals

Lähes koko ihmisen voi jo korjata varaosilla – pään siirtokin ehkä onnistuisi, mutta millaisin tuloksin? YLE uutiset 9.3.2016
Read the article here (in Finnish)

Kantasoluista parannuskeinoja silmäsairauksiin, Kemianteollisuus, 17.11.2015
Read the article here (in Finnish)

Kantasolujen spesialisti, Helsingin sanomat 2.10.2015
Read the article here (in Finnish)

Kantasoluilla täsmähoitoja silmäsairauksiin?  YLE Akuutti 14.9.2015
Read the article here (in Finnish)

Uusia hoitoja luvassa: Kantasoluista tehdään jo verta ja vaginoita. Helsingin Sanomat. 11.3.2015.
Read the article here (in Finnish)

Katseen parantajat. Aikalainen. 2.3.2015.
Read the article here (in Finnish)

Kantasoluista sykkiviä sydänsoluja. Lääketieteellinen Aikakauskirja Duodecim 2014;130(19):2001-8
Read the article here (in Finnish)

Luuta leukaan rasvan kantasoluista. Lääketieteellinen Aikakauskirja Duodecim. 2014;130(19):2009-16
Read the article here (in Finnish).

Ihmisen kantasolut – ihmeparantajat? Lääketieteellinen Aikakauskirja Duodecim 2014;130(19):1961-2
Read the article here (in Finnish).

Kantasoluista luodaan uutta vientituotetta. Utain. 10.12.2014.
Read the article here (in Finnish)

Tampereella kehitetään ihmisen varaosia kahden yliopiston yhteisvoimin. Yle Uutiset. 3.6.2014.
Read the article here (in Finnish)

Tutkija kastelee aivoja kolmesti viikossa. Yle Uutiset. 18.1.2013.
Read the article here (in Finnish)

Tampereella rakennetaan hermoverkkoja. TEK verkkolehti. 5.9.2012.
Read the article here (in Finnish)

Rasvakudoksen kantasoluista varaosia kudosvaurioiden hoitoon. SIC! Lääketietoa Fimeasta. 3/2011.
Read the article here (in Finnish)

Reino Leisti sai kantasoluista kasvatetun ylaleuan. Suomen Kuvalehti. 31.1.2008
Read the article here (in Finnish)

Videos and presentations

Tästä elämästä: Ihmisen varaosat. 6.6.2012, Yle Areena. Watch the video here (in Finnish)

Näin sykkivät Tampereella valmistetut elävät sydänsolut, katso videot! Aamulehti. 21.8.2011.
Watch the videos and read the article here (in Finnish)

 

Selected articles in scientific journals

Adult Stem Cell Group

Sándor GKB., Thesleff T, Numminen J, Lehtimäki K, Niskakangas T, Mannerström B, Miettinen S, Seppänen R, Rautiainen M, Öhman J. Adipose stem cells used to reconstruct 13 cases with cranio-maxillofacial hard-tissue defects. Stem Cells Transl Med. 2014 Apr;3(4):530-40.

Kuismanen K, Sartoneva R, Haimi S, Mannerström B, Tomas E, Miettinen S, Nieminen K. Autologous adipose stem cells in treatment of female stress urinary incontinence; results of a pilot study. Stem Cells Transl Med. 2014 Aug;3(8):936-41. doi: 10.5966/sctm.2013-0197. Epub 2014 Jul 1.

Patrikoski M, Sivula J, Huhtala H, Helminen M, Salo F, Mannerström B, Miettinen S. Different culture conditions modulate the immunological properties of adipose stem cells. Stem Cells Transl Med. 2014 Oct;3(10):1220-30. doi:10.5966/sctm.2013-0201. Epub 2014 Aug 13.

Hunter DJ, Bardet C, Mouraret S, Liu B, Singh G, Sadoine J, Dhamdhere G, Smith A, Tran XV, Joy A, Rooker S, Suzuki S, Vuorinen A, Miettinen S, Chaussain C, Helms JA. Wnt Acts as a Pro-Survival Signal to Enhance Dentin Regeneration. J Bone Miner Res. 2015 Jan 1. doi: 10.1002/jbmr.2444. [Epub ahead of print] PubMed PMID: 25556760.

Ojansivu M, Vanhatupa S, Björkvik L, Häkkänen H, Kellomäki M, Autio R, Ihalainen JA, Hupa L, Miettinen S. Bioactive Glass Ions as Strong Enhancers of Osteogenic Differentiation in Human Adipose Stem Cells. Acta Biomater. 2015 Jul 15;21:190-203.

Vanhatupa S, Ojansivu M, Autio R, Juntunen M, Miettinen S. BMP-2 induces donor dependent osteogenic and adipogenic differentiation in human adipose stem cells. Accepted for publication in Stem Cells Transl Med.

 

Biomaterials and Tissue Engineering Group

Uurto, I, Hämäläinen M, Suominen V, Laurila M, Kotsar A, Isotalo T, Tammela TLJ, Kellomäki M, Salenius J-P. Muraglitazar eluting bioabsorbable vascular stent inhibits neointimal hyperplasia in procine iliac arteries. Journal of Vascular and Interventional Radiology 2015 26(1);124-130.

Käpylä, Elli; Sedlacik, Tomas; Aydogan, Dogu Baran; Viitanen, Jouko; Rypacek, Frantisek; Kellomäki, Minna 2014. Direct laser writing of synthetic poly(amino acid) hydrogels and poly(ethylene glycol) diacrylates by two-photon polymerization. Materials Science and Engineering: C vol. 43, 280-289. http://dx.doi.org/10.1016/j.msec.2014.07.027

Turunen S, Käpylä E, Lähteenmäki M, Ylä-Outinen L, Narkilahti S, and Kellomäki M. Direct laser writing of microstructures for in vitro growth guidance of human pluripotent stem cell derived neuronal cells. Optics and Lasers in Engineering 55:197-204, 2014. http://dx.doi.org/10.1016/j.optlaseng.2013.11.003

Huttunen M, Kellomäki M. Strength retention behaviour of oriented PLLA, 96L/4D PLA and 80L/20D,L PLA. Biomatter 2013 Sep 11;3(4). pii: e26395.

Some newest publications as examples:

Haaparanta A-M, Uppstu P, Hannula M, Ellä V, Rosling A, Kellomäki M. Improved dimensional stability with bioactive glass fibre skeleton in poly(lactide-co-glycolide) porous scaffolds for tissue engineering. Materials Science and Engineering: C, 2015 56;457-466.

Figueiras, Edite; Soto, Ana M.; Jesus, Danilo; Lehti, M.; Koivisto, J.; Parraga, J.E.; Silva-Correia, J.; Oliveira, J.M.; Reis, R.L.; Kellomäki, M.; Hyttinen, J. 2014. Optical projection tomography as a tool for 3D imaging of hydrogels. Biomedical Optics Express vol. 5, num. 10, 3443-3449. http://dx.doi.org/10.1364/BOE.5.003443.

Haaparanta A-M, Järvinen E, Cengiz IF, Ellä V, Kokkonen HT, Kiviranta I, Kellomäki M. Preparation and characterization of collagen/PLA, chitosan/PLA and collagen/chitosan/PLA hybrid scaffolds for cartilage tissue engineering. JMS:MIM 12/2013, DOI: 10.1007/s10856-013-5129-5

We choose the functionalization strategy based on application area and materials:

Käpylä, E, Sorkio, A, Teymouri, S, Lahtonen, K, Vuori, L, Valden, M, Skottman, H, Kellomäki, M, Juuti-Uusitalo, K. Ormocomp® -modified glass as culture substratum for human embryonic stem cell-derived retinal pigment epithelial cells. Langmuir 2015 30(48);14555-14565.

Uniform and electrically conductive biopolymer-doped polypyrrole coating for fibrous PLA. Hiltunen M., Pelto J., Ellä V., Kellomäki M. In the press.

Pelto J, Pälli A, Hämäläinen M, Talvitie E, Hyttinen J, Mannerström B, Suuronen R, Kellomäki M, Miettinen S, Haimi S. The effects of 3D polypyrrole coated polylactide scaffolds on adipose stem cells under electrical stimulation. In the press.

 

Computational Biophysics and Imaging Group (CBIG)

Ahola, Antti; Kiviaho, Anna L.; Larsson, Kim; Honkanen, Markus; Aalto-Setälä, Katriina; Hyttinen, Jari 2014. Video image-based analysis of single human induced pluripotent stem cell derived cardiomyocyte beating dynamics using digital image correlation. BioMedical Engineering Online vol. 13, num. 1,  http://dx.doi.org/10.1186/1475-925X-13-39

Kiviaho A; Ahola A; Larsson K; Penttinen K; Swan H; Pekkanen-Mattila M; Venäläinen H; Paavola K; Hyttinen J; Aalto-setälä K. Long QT syndrome type 1 -specific cardiomyocytes carrying different mutations reveal distinct electrophysiological and mechanical beating phenotypes. IJC Heart & Vasculature 2015 (Accepted)

First “in silica medicine” approach for hESC derived cardiomyocytes providing a comprehensive analysis of various ion channel inhinbitors:

Paci M, Hyttinen J, Rodriguez B, Severi S.  Human induced pluripotent stem cell‐derived versus adult cardiomyocytes: an in silico electrophysiological study on ionic current block effects. British Journal of Pharmacology, 2015 (accepted)

Puthanmadam Subramaniyam, Narayan; Hyttinen, Jari 2014.  Characterization of dynamical systems under noise using recurrence networks: Application to simulated and EEG data. Physics Letters A vol. 378, num. 46, 3464-3474. http://dx.doi.org/10.1016/j.physleta.2014.10.005

Subramaniyam N, Hyttinen J.  Dynamics of intracranial electroencephalographic recordings from epilepsy patients using univariate and bivariate recurrence networks. Physical Review E 2015 (accepted).

Nanoparticle based X-ray bioimaging:

Zou J, Hannula M, Misra S, Feng H, Labrador R, Aula A, Hyttinen J and Pyykkö I.: Micro CT visualization of silver nanoparticles in the middle and inner ear of rat and transportation pathway after transtympanic injection.  : Journal of Nanobiotechnology. 2015 (accepted)

Zou J, Hannula M, Lehto L, Feng H, Lähelmä J, Aula A.S., Hyttinen J, Pyykkö I.  X-ray microtomographic confirmation of the reliability of CBCT in identifying the scalar location of cochlear implant electrode after round window insertion. Hearing research 2015 (accepted)

 

Eye group

Retinal cells and biomaterials

Sorkio, A., Vuorimaa-Laukkanen, E., Hakola, H., Liang, H., Ujula, T.,Valle-Delgado, JJ.,  Österberg, M., Yliperttula, M., and Skottman, H. Biomimetic Collagen I and IV double layer Langmuir-Schaeffer films as microenvironment for human pluripotent stem cell derived retinal pigment epithelial cells. Biomaterials. 2015 May;51:257-69. doi: 10.1016/j.biomaterials.2015.02.005. Epub 2015 Feb 20.

Sorkio, A., Porter, PJ., Juuti-Uusitalo, K., Meenan, BJ., Skottman, H., Burke, GA. Atmospheric pressure plasma treatment increases the attachment and maturation of human pluripotent stem cell derived retinal pigment epithelial cells on biodegradable polymeric electrospun scaffolds. Tissue engineering Part A, in press.

Sorkio, A., Hongisto, H., Kaarniranta, K., Uusitalo H., Juuti-Uusitalo, K., Skottman, H. Structure and barrier properties of human embryonic stem cell derived retinal pigment epithelial cells are affected by extracellular matrix protein surfaces. Tissue engineering Part A. 2014, Feb;20(3-4):622-34.

Juuti-Uusitalo, K., Delporte, C., Gregoire, F., Perret, J., Huhtala, H., Savolainen, V., Nymark, S., Uusitalo, H., Willermain, F., Skottman, H. Aquaporin expression and function in human pluripotent stem cell-derived retinal pigmented epithelial cells. Invest Ophthalmol Vis Sci, 2013 May 1;54(5):3510-9.

Subrizi, A., Hiidenmaa, H., Ilmarinen, T., Nymark, S., Dubruel, P., Uusitalo, H., Yliperttula, M.,  Urtti, A., Skottman, H. Generation of hESC-derived retinal pigment epithelium on biopolymer coated polyimide membranes. Biomaterials. 2012 Nov;33(32):8047-54. Epub 2012 Aug 11.

Juuti-Uusitalo, K., Vaajasaari, H., Ryhänen, T., Narkilahti, S., Suuronen, R., Mannermaa, E., Kaarniranta, K., Skottman, H. Efflux protein expression in human pluripotent stem cell -derived retinal pigment epithelial cells.  PLoS One. 2012;7(1):e30089. Epub 2012 Jan 17.

Corneal cells

Mikhailova, A., Ilmarinen, T., Uusitalo, H., Skottman, H. Small molecule induction promotes corneal epithelium cell differentiation from human induced pluripotent stem cells. Stem Cell Reports, 2014. Feb 6;2(2):219-31.

Stem cell biology:

Hongisto, H., Vuoristo, S., Mikhailova, A., Suuronen, R., Virtanen, I., Otonkoski, T. and Skottman, H. Laminin 511expression is associated  with the functionality of feeder cells in human embryonic stem cell culture. Stem Cell Research, 2012 Jan;8(1):97-108. Epub 2011 Aug 27.

Skottman, H. Derivation and characterization of three new human embryonic stem cell lines in Finland. In Vitro Cell Dev Biol Anim. 2010 Apr;46(3-4):206-9. Epub 2010 Feb 23.

 

Heart group

Penttinen K, Siirtola H, Àvalos-Salguero J, Vainio T, Juhola M, Aalto-Setälä K. Novel Analysis Software for Detecting and Classifying Ca2+ Transient Abnormalities in Stem Cell-Derived Cardiomyocytes. PLoS One. 2015 Aug 26;10(8):e0135806.

Penttinen K, Swan H, Vanninen S, Paavola J, Lahtinen AM, Kontula K, Aalto-Setälä K. Antiarrhythmic Effects of Dantrolene in Patients with Catecholaminergic Polymorphic Ventricular Tachycardia and Replication of the Responses Using iPSC Models. PLoS One 2015 ;10(5)e0125366

Juhola M, Penttinen K, Joutsijoki H, Varpa K, Saarikoski J, Rasku J, Siirtola H, Iltanen K, Laurikkala J, Hyyrö H, Hyttinen J, Aalto-Setälä K. Signal analysis and classification methods for the calcium transient data of stem cell-derived cardiomyocytes. Comput Biol Med 2015 ;611-7

Spencer CI, Baba S, Nakamura K, Hua EA, Sears MA, Fu CC, Zhang J, Balijepalli S, Tomoda K, Hayashi Y, Lizarraga P, Wojciak J, Scheinman MM, Aalto-Setälä K, Makielski JC, January CT, Healy KE, Kamp TJ, Yamanaka S, Conklin BR. Calcium transients closely reflect prolonged action potentials in iPSC models of inherited cardiac arrhythmia. Stem Cell Reports 2014 ;3(2)269-81

Jääskeläinen P, Heliö T, Aalto-Setälä K, Kaartinen M, Ilveskoski E, Hämäläinen L, Melin J, Kärkkäinen S, Peuhkurinen K, Nieminen MS, Laakso M, , Kuusisto J. A new common mutation in the cardiac beta-myosin heavy chain gene in Finnish patients with hypertrophic cardiomyopathy. Ann Med 2014 ;46(6)424-9

Ahola A, Kiviaho AL, Larsson K, Honkanen M, Aalto-Setälä K, Hyttinen JVideo image-based analysis of single human induced pluripotent stem cell derived cardiomyocyte beating dynamics using digital image correlation. Biomed Eng Online 2014 ;1339

Vuorenpää H, Ikonen L, Kujala K, Huttala O, Sarkanen JR, Ylikomi T, Aalto-Setälä K, Heinonen T. Novel in vitro cardiovascular constructs composed of vascular-like networks and cardiomyocytes. In Vitro Cell Dev Biol Anim 2014 ;50(4)275-86

Kreutzer J, Ikonen L, Hirvonen J, Pekkanen-Mattila M, Aalto-Setälä K, Kallio P. Pneumatic cell stretching system for cardiac differentiation and culture. Med Eng Phys 2014 ;36(4)496-501

Lahti AL, Kujala VJ, Chapman H, Koivisto AP, Pekkanen-Mattila M, Kerkelä E, Hyttinen J, Kontula K, Swan H, Conklin BR, Yamanaka S, Silvennoinen O, Aalto-Setälä K. Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture. Dis Model Mech. 2012 Mar;5(2):220-30.

 

Micro- and Nanosystems Research Group

Kreutzer, J. et al. Pneumatic Cell Stretching System for Cardiac Differentiation and Culture. Medical Engineering & Physics, Volume 36, No 4, April 2014, pp. 496-501. DOI: 10.1016/j.medengphy.2013.09.008

Saketi, P., von Essen, M., Mikczinski, M., Heinemann, S., Fatikow, S. & Kallio, P. A Flexible Microrobotic Platform for Handling Microscale Specimens of Fibrous Materials for Microscopic Studies. Journal of Microscopy. Volume 248, Issue 2, November 2012, pp. 163–171

 

Neurogroup

Toivonen S, Ojala M, Hyysalo A, Ilmarinen T, Lundin K, Palgi J, Weltner J, Trokovic R, Rajala K, Pekkanen-Mattila M, Äänismaa R, Silvennoinen O, Skottman H, Narkilahti S, Aalto-Setälä K, Otonkoski T (2013) Comparative analysis of targeted differentiation of hiPSC and hESC reveals variability associated with incomplete transgene silencing in retrovirally derived hiPSC lines. Stem Cells Transl Med. Feb;2(2):83-93.

Kapucu FE, Tanskanen JMA, Mikkonen JE, Ylä-Outinen L, Narkilahti S and Hyttinen JAK (2012). Burst analysis tool for developing neuronal networks exhibiting highly varying action potential dynamics. Front. Comput. Neurosci. 6:38. doi: 10.3389/fncom.2012.00038.

Kreutzer J, Ylä-Outinen L, Kärnä P, Kaarela T, Skottman H, Mikkonen J, Narkilahti S, Kallio P (2012) Structured PDMS chambers for enhanced human neuronal cell activity on MEA platforms. Journal of Bionic Engineering 2012, 9(1):1-10.

Ylä-Outinen L, Joki T, Varjola M, Skottman H, Narkilahti S (2012) Three dimensional growth matrix for human embryonic stem cell-derived neuronal cells. The Journal of Tissue Engineering and Regenerative Medicine. May 18.

Sundberg M, Hyysalo A, Skottman H, Shin S, Vemuri M, Suuronen R, Narkilahti S (2011) A xeno-free culturing protocol for pluripotent stem cell-derived oligodendrocyte precursor cell production. Regenerative Medicine, Jul;6(4):449-60.

Sundberg M, Andersson P-H, Åkesson E, Odeberg J, Holmberg L, Inzunza J, Falci S, Öhman J, Suuronen R, Skottman H, Lehtimäki K, Hovatta O, Narkilahti S, Sundström E (2011) Markers of pluripotency and differentiation in human neural precursor cells derived from embryonic stem cells and CNS tissue. Cell Transplantation, 20(2):177-91.

Lappalainen RS, Salomäki M, Ylä-Outinen L, Heikkilä TJ, Hyttinen JAK, Pihlajamäki H, Suuronen R, Skottman H, Narkilahti S (2010) Similarly derived and cultured hESC lines show variation in their developmental potential towards neuronal cells in long-time culture. Regenerative Medicine, Sep;5(5):749-62.

Ylä-Outinen L, Heikkilä J, Skottman H, Suuronen R, Äänismaa R, Narkilahti S (2010) Human cell-based micro electrode array platform for studying neurotoxicity. Frontiers in Neuroengineering 3(111):1-9.

Heikkilä T, Ylä-Outinen L, Tanskanen J, Lappalainen R, Skottman H, Suuronen R, Hyttinen J, Narkilahti S (2009) Human embryonic stem cell-derived neuronal cells form spontaneously active neuronal networks in vitro. Exp Neurol. 218(1):109-16.

Sundberg M Jansson L, Ketolainen J, Pihlajamäki H, Suuronen R, Skottman H, Hovatta O, Narkilahti S (2009) CD marker expression profiles of human embryonic stem cells and their neural derivatives, determined using flow cytometric analysis, reveal a novel CD marker for exclusion of pluripotent stem cells. Stem Cell Res. Mar;2(2):113-24.

 

Sensor Technology and Biomeasurements

Salpavaara, T., Järveläinen, M., Seppälä, S., Yli-Hallila, T., Verho, J., Vilkko, M., Lekkala, J. and Levänen, E. 2015. Passive resonance sensor based method for monitoring particle suspensions. Sensors and Actuators B: Chemical. 219, p. 324-330.

Roine, Antti; Veskimäe, Erik; Tuokko, Antti; Kumpulainen, Pekka; Koskimäki, Juha; Keinänen, Tuomo A.; Häkkinen, Merja R.; Vepsäläinen, Jouko; Paavonen, Timo; Lekkala, Jukka; Lehtimäki, Terho; Tammela, Teuvo L.; Oksala, Niku K.J. 2014. Detection of Prostate Cancer by an Electronic Nose; A Proof of Principle Study. The Journal of Urology vol. 192, num. 1, 230-235.

Peltokangas, Mikko; Vehkaoja, Antti; Verho, Jarmo; Huotari, Matti; Röning, Juha; Lekkala, Jukka 2014. Monitoring Arterial Pulse Waves With Synchronous Body Sensor Network. IEEE Journal of Biomedical and Health Informatics vol. 18, num. 6, 1781-1787.

Vehkaoja, Antti; Rajala, Satu; Kumpulainen, Pekka; Lekkala, Jukka, 2013. Correlation approach for the detection of the heartbeat intervals using force sensors placed under the bed posts. Journal of Medical Engineering & Technology, vol. 37, num. 5, 327-333.

Rantanen, Ville; Venesvirta, Hanna; Spakov, Oleg; Verho, Jarmo; Vetek, Akos; Surakka, Veikko; Lekkala, Jukka 2013. Capacitive Measurement of Facial Activity Intensity. IEEE Sensors Journal, vol. 13, num. 11, 4329-4338.

Ryynänen, T., Ylä-Outinen, L., Narkilahti, S., Tanskanen, J.M.A., Hyttinen, J., Hämäläinen, J., Leskelä, M. and Lekkala, J. 2012. Atomic layer deposited iridium oxide thin film as microelectrode coating in stem cell applications. Journal of Vacuum Science & Technology A, 30/4, pp. 1-5., and Virtual Journal of Biological Physics Research vol. 23, issue 9.

Rajala, S. and Lekkala, J. 2012. Film-Type Sensor Materials PVDF and EMFi in Measurement of Cardiorespiratory Signals — A Review, IEEE Sensors Journal 12, pp. 439 – 446.

Ryynänen T., Kujala V., Ylä-Outinen L., Korhonen I., Tanskanen J., Aalto-Setälä K., Hyttinen J., Kerkelä E., Narkilahti S. and Lekkala, J. 2011. All-Titanium Microelectrode Array for Field Potential Measurements from Neurons and Cardiomyocytes – a Feasibility Study. Micromachines 2, pp. 394-409.